Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 55

会议视频 50

会议信息 2

年份

2023 6

2022 10

2021 52

2020 6

2019 5

2018 5

2017 3

2016 1

2015 4

2014 4

2013 2

2012 3

2010 2

2002 2

2001 1

2000 1

展开︾

关键词

工程管理 18

环境 9

智能制造 5

仿生机器人 4

代谢与免疫 3

医学 2

建筑科学 2

6G；广域覆盖信令小区；多维资源分配；深度Q网络（DQN） 1

COVID-19 1

DQ&P 1

Engineering期刊工作 1

GC-Q-TOFMS 1

H∞控制；零和动态博弈；强化学习；自适应动态规划；极小极大Q-学习；策略迭代 1

KTP 1

LC-Q-TOFMS 1

LED，颜色漂移，光通量衰减，流明衰减 1

Q&P 1

Q值监测 1

SEIR+Q传染病动力学模型 1

展开︾

检索范围：

排序：展示方式：

Clinical significance of CD34⁺CD117^dim/CD34⁺CD117^bri myeloblast-associated gene expression in t(8;21) acute myeloid leukemia

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

《医学前沿（英文）》 2021年第15卷第4期页码 608-620 doi: 10.1007/s11684-021-0836-7

摘要： t(8;21)(q22;q22) acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy with a high relapse rate in China. Two leukemic myeloblast populations (CD34 CD117 and CD34 CD117 ) were previously identified in t(8;21) AML, and CD34 CD117 cell proportion was determined as an independent factor for this disease outcome. Here, we examined the impact of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression on t(8;21) AML clinical prognosis. In this study, 85 patients with t(8;21) AML were enrolled. The mRNA expression levels of CD34 CD117 -associated genes ( , , and ) and CD34 CD117 -associated genes ( , , and ) were measured using quantitative reverse transcription PCR. Associations between gene expression and clinical outcomes were determined using Cox regression models. Results showed that patients with high , , or expression had significantly inferior overall survival (OS), whereas those with high or expression showed relatively favorable prognosis. Univariate analysis revealed that CD19, CD34 CD117 proportion, mutation, minimal residual disease (MRD), and expression levels of , , , and were associated with OS. Multivariate analysis indicated that mutation, MRD and and expression levels were independent prognostic variables for OS. Identifying the clinical relevance of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression may provide new clinically prognostic markers for t(8;21) AML.

关键词： t(8 21)(q22 q22) AML CD34⁺CD117^dim/ CD34⁺CD117^bri cell population gene expression prognosis

HTML PDF 收藏

Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

《结构与土木工程前沿（英文）》 2014年第8卷第4期页码 448-455 doi: 10.1007/s11709-014-0262-x

摘要： Rock mass classification system is very suitable for various engineering design and stability analysis. classification method is confirmed by Japan Highway Public Corporation that this method can figure out either strength or deformability of rock mass, further appropriating the amount of rock bolts, thickness of shotcrete, and size of pitch of steel ribs just after the blasting procedure. Based on these advantages of method, in this study, according to data of five deep and long tunnels in Iran, two equations for estimating the value of method from and classification systems were developed. These equations as a new method were able to optimize the support system for and classification systems. From classification and its application in these case studies, it is pointed out that the method for the design of support systems in underground working is more reliable than the and classification systems.

关键词： JH classification Q and RMR classification new method

HTML PDF 收藏

An approach for evaluating fire resistance of high strength Q460 steel columns

Wei-Yong WANG, Guo-Qiang LI, Bao-lin YU

《结构与土木工程前沿（英文）》 2014年第8卷第1期页码 26-35 doi: 10.1007/s11709-014-0239-9

摘要： To develop a methodology for evaluating fire resistance of high strength Q460 steel columns, the load bearing capacity of high strength Q460 steel columns is investigated. The current approach of evaluating load bearing capacity of mild steel columns at room temperature is extended to high strength Q460 steel columns with due consideration to high temperature properties of high strength Q460 steel. The critical temperature of high strength Q460 steel column is presented and compared with mild steel columns. The proposed approach was validated by comparing the predicted load capacity with that evaluated through finite element analysis and test results. In addition, parametric studies were carried out by employing the proposed approach to study the effect of residual stress and geometrical imperfections. Results from parametric studies show that, only for a long column (slenderness higher than 75), the magnitude and distribution mode of residual stress have little influence on ultimate load bearing capacity of high strength Q460 steel columns, but the geometrical imperfections have significant influence on any columns. At a certain slenderness ratio, the stability factor first decreases and then increases with temperature rise.

关键词： high strength Q460 steel load bearing capacity temperature

HTML PDF 收藏

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

null

《医学前沿（英文）》 2012年第6卷第3期页码 248-262 doi: 10.1007/s11684-012-0206-6

摘要：

The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is present in approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid leukemia (AML) patients. Both human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis in the absence of secondary events. In this review, we discuss the pathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-ETO to induce AML in vivo. We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the fusion protein itself, the proteins that bind to it, or the genes that it regulates. Recently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may be coming sometime soon.

关键词： AML1-ETO mouse model leukemia t(8 21) pathway hits mutation hematopoiesis Kasumi-1 CD34+

HTML PDF 收藏

Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

《医学前沿（英文）》 2019年第13卷第3期页码 388-397 doi: 10.1007/s11684-018-0624-1

摘要： Collaboration of c-KIT mutations with AML1–ETO (AE) has been demonstrated to induce t(8; 21) acute myeloid leukemia (AML). Targeted therapies designed to eliminate AE and c-KIT oncoproteins may facilitate effective treatment of t(8; 21) AML. Homoharringtonine (HHT) features activity against tumor cells harboring c-KIT mutations, whereas oridonin can induce t(8; 21) AML cell apoptosis and AE cleavage. Therefore, studies should explore the efficacy of combination therapy with oridonin and HHT in t(8; 21) AML. In this study, we investigated the synergistic effects and mechanism of oridonin combined with HHT in t(8; 21) AML cell line and mouse model. The two drugs synergistically inhibited cell viability and induced significant mitochondrial membrane potential loss and apoptosis. Oridonin and HHT induced significant downregulation of c-KIT and its downstream signaling pathways and promoted AE cleavage. HHT increased intracellular oridonin concentration by modulating the expressions of MRP1 and MDR1, thus enhancing the effects of oridonin. The combination of oridonin and HHT prolonged t(8; 21) leukemia mouse survival. In conclusion, oridonin and HHT exert synergistic effects against t(8; 21) leukemia and , thereby indicating that their combination may be an effective therapy for t(8; 21) leukemia.

关键词： AML1–ETO c-KIT homoharringtonine oridonin t(8 21) AML synergistic effect

HTML PDF 收藏

R158Q and G212S, novel pathogenic compound heterozygous variants in of Gitelman syndrome

《医学前沿（英文）》 2022年第16卷第6期页码 932-945 doi: 10.1007/s11684-022-0963-9

摘要： The dysfunction of Na⁺-Cl⁻ cotransporter (NCC) caused by mutations in solute carrier family12, member 3 gene (SLC12A3) primarily causes Gitelman syndrome (GS). In identifying the pathogenicity of R158Q and G212S variants of SLC12A3, we evaluated the pathogenicity by bioinformatic, expression, and localization analysis of two variants from a patient in our cohort. The prediction of mutant protein showed that p.R158Q and p.G212S could alter protein’s three-dimensional structure. Western blot showed a decrease of mutant Ncc. Immunofluorescence of the two mutations revealed a diffuse positive staining below the plasma membrane. Meanwhile, we conducted a compound heterozygous model—Ncc R156Q/G210S mice corresponding to human NCC R158Q/G212S. Ncc^R156Q/G210S mice clearly exhibited typical GS features, including hypokalemia, hypomagnesemia, and increased fractional excretion of K⁺ and Mg²⁺ with a normal blood pressure level, which made Ncc^R156Q/G210S mice an optimal mouse model for further study of GS. A dramatic decrease and abnormal localization of the mutant Ncc in distal convoluted tubules contributed to the phenotype. The hydrochlorothiazide test showed a loss of function of mutant Ncc in Ncc^R156Q/G210S mice. These findings indicated that R158Q and G212S variants of SLC12A3 were pathogenic variants of GS.

关键词： Gitelman syndrome mouse model compound heterozygous hypokalemia Slc12a3

HTML PDF 收藏

GC/LC-Q-TOFMS 两种技术联用同时筛查水果蔬菜中733 种农药残留 Article

庞国芳, 常巧英, 白若镔, 范春林, 张紫娟, 闫宏远, 吴兴强

《工程（英文）》 2020年第6卷第4期页码 432-441 doi: 10.1016/j.eng.2019.08.008

摘要：

本文通过创建LC-Q-TOFMS（525种农药）和GC-Q-TOFMS（485种农药和209种PCBs）两大精确质谱数数据库，开发了一次样品制备、两种高分辨质谱联用同时检测733种农药化学污染物残留的检测方法通过8种代表性水果蔬菜对联用技术的筛查农药范围、灵敏度、回收率和重现性等方法效能评价，显示出这项联用技术有三方面优势：①两种技术联用与单种技术相比，其发现能力分别提高了51.1%（GC-Q-TOFMS，485种）和39.6%（LC-Q-TOFMS，525种）；②联用技术能够满足78%的农药筛查限（SDL）低于10 μg·kg^–1，满足国际&ldquo

关键词：农药残留 GC-Q-TOFMS LC-Q-TOFMS 精确质量数据库谱图库水果蔬菜

HTML PDF 收藏

新型电光调Q腔内倍频绿光激光器

陈飞,霍玉晶,何淑芳,冯立春

《中国工程科学》 2000年第2卷第4期页码 39-42

摘要：

本文报道了一种新型的LD泵浦Nd:YVO₄-KTP电光调Q绿光激光器，用单块KTP晶体同时作为电光调Q开关和Ⅱ类相位匹配的倍频晶体，减少了腔内损耗，提高了效率，得到了脉宽为12ns

关键词： KTP 绿光激光器电光调Q开关倍频

HTML PDF 收藏

Q&P 工艺理念在热轧先进高强度钢中的应用研究

袁国,康健,张贺,李云杰,胡虹玲,王国栋

《中国工程科学》 2014年第16卷第1期页码 59-65

摘要：

为满足汽车工业轻量化发展要求，以Q&P（quenching & partitioning）工艺为基础的先进高强度钢受到了广泛关注，为使其在普通热连轧生产线上实现工业化并广泛应用，本文对Q&P理念在热轧工艺中的应用进行了基础研究。结果表明在传统热处理Q&P工艺中引入热变形处理后，组织细化显著，并获得了一定量的残余奥氏体。实验钢在保持较高强度的同时获得了较大的强塑积，结合目前国内热连轧生产线以超快冷系统为核心的新一代控轧控冷（TMCP）技术的应用，确定了在热连轧生产线生产热轧Q&P钢（DQ（direct quenching

关键词：先进高强度钢 Q&P DQ&P 热轧残余奥氏体

HTML PDF 收藏

光传送网中光监控通道信号Q值在线监测技术

唐勇,孙小菡,张明德,丁东

《中国工程科学》 2001年第3卷第12期页码 71-75

摘要：依据Q值与误码率（BER）的一一对应关系，提出了一种可在线监测OSC信号Q值的方案，并基于数字信号处理芯片（DSP）技术设计了监测模块，实现了OSC信号在线Q值监测。

关键词：光传送网（OTN）光监控通道（OSC）运行、管理和维护（OAM） Q值监测

HTML PDF 收藏

A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation

null

《医学前沿（英文）》 2018年第12卷第3期页码 324-329 doi: 10.1007/s11684-017-0558-z

摘要：

Splenic lymphoma with villous lymphocytes (SLVL) or splenic marginal zone lymphoma with circulating villous lymphocytes is rare, and prolymphocytic transformation of SLVL is rarer. At present, only one case of SLVL with t(8;14)(q24;q32) translocation has been reported. In this study, we report a case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) chromosome translocation that we inclined to SLVL with a prolymphocytic transformation. A 73-year-old female showed marked hepatosplenomegaly and high lymphocytosis (lymphocytes>200×10⁹/L). The abnormal lymphocytes had short coarse villi and round nuclei with prominent nucleoli. The immunophenotypes showed CD19⁺, CD20⁺, HLA-DR⁺, CD22⁺, CD5⁺, Kappa⁺, CD25^dim, CD71^dim, Lambda⁻, CD7⁻, CD10⁻, CD23⁻, CD34⁻, CD33⁻, CD13⁻, CD14⁻, CD117⁻, CD64⁻, CD103⁻, and CD11c⁻. The karyotype showed complex abnormality: 46XX,+3,−10, t(8;14)(q24;q32)[11]/46XX[⁹]. The cytoplasmic projection, immunological characteristics, and trisomy 3 chromosome abnormality supported the diagnosis of SLVL. However, the presence of prominent nucleoli and high lymphocytosis suggested prolymphocytic transformation, probably as a result of t(8,14) chromosome translocation. In this report, we described an unusual case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation, which could provide help in the diagnosis and differential diagnosis of B-lymphocytic proliferative diseases.

关键词： splenic lymphoma with villous lymphocytes splenic marginal zone lymphoma transformation chromosome translocation

HTML PDF 收藏

Hot deformation behavior of a novel bimetal consisting of BTW1 and Q345R characterized by processing

Pengtao LIU, Lifeng MA, Weitao JIA, Tao WANG, Guanghui ZHAO

《机械工程前沿（英文）》 2019年第14卷第4期页码 489-495 doi: 10.1007/s11465-019-0554-x

摘要： Only a few studies have been conducted on the flow behavior of the novel BTW1/Q345R bimetal, which is widely used in coal equipment. In this work, compression tests were conducted on BTW1/Q345R bimetal at a temperature range of 950 °C–1200 °C and strain rates of 0.05, 0.5, 5, and 15 s by using a Gleeble-3800 thermomechanical simulator. A constitutive equation was validated by referring to the Arrhenius equation during the characterization of hot workability. The computed apparent activation energy of the BTW1/Q345R bimetal was 360 kJ/mol, and processing maps under different strain conditions were drawn. Analysis of the stress-strain relationship revealed that work hardening exerted a dominant effect on the thermal deformation of the BTW1/Q345R bimetal. The processing maps predicted that the optimal processing interval will increase with strain. Results showed that thermal deformation of the BTW1/Q345R bimetal should proceed when the temperature range varies from 1182 °C to 1200 °C and the strain rate interval is from 4.2 to 15 s .

关键词： BTW1/Q345R bimetal constitutive equation processing map work hardening

HTML PDF 收藏

基于深度Q学习网络与新训练算法的服务机器人主动物品检测模型 Research Article

刘少鹏,田国会,崔永成,邵旭阳

《信息与电子工程前沿（英文）》 2022年第23卷第11期页码 1673-1683 doi: 10.1631/FITEE.2200109

摘要：因此，本文提出一种基于深度Q学习网络的AOD模型，并设计了一种新的模型训练算法。该模型旨在拟合各种动作Q值，包括状态空间、特征提取和多层感知机。

关键词：主动物品检测；深度Q学习网络；训练算法；服务机器人

HTML PDF 收藏

Development of barium@alginate adsorbents for sulfate removal in lithium refining

Lisa Xu, Kaifei Chen, George Q. Chen, Sandra E. Kentish, Gang (Kevin) Li

《化学科学与工程前沿（英文）》 2021年第15卷第1期页码 198-207 doi: 10.1007/s11705-020-1968-z

摘要： The demand for lithium has been steadily growing in recent years due to the boom of electric cars. High purity lithium is commonly used in the manufacture of battery grade lithium electrolyte. Sulfate residuals originating from acid leaching of lithium ores must be limited to below 20 mg·L during refining. There are methods to remove sulfate such as membrane processing and chemical precipitation using barium salts. However, membrane separation is unable to achieve the required purity while chemical precipitation often causes secondary contamination with barium and requires extra filtration processes that lead to increased processing costs. In this study, we developed a polymeric matrix entrapped with barium ions as a novel adsorbent to selectively adsorb sulfate in aqueous solutions. The adsorbent was prepared by dropwise injection method where alginate droplets were crosslinked with barium to form hydrogel microcapsules. In a typical scenario, the microcapsules had a diameter of 3 mm and contained 5 wt-% alginate. The microcapsules could successfully reduce sulfate concentration in a solution from 100 to 16 mg·L , exceeding the removal target. However, the microcapsules were mechanically unstable in the presence of an excess amount of sulfate. Hence, calcium ions were added as a secondary crosslinking agent to improve the integrity of the microcapsules. The two-step Ca/Ba@alginate microcapsules showed an exceptional adsorption performance, reducing the sulfate concentration to as low as 0.02 mg·L . Since the sulfate selective microcapsules can be easily removed from the aqueous system and do not result in secondary barium contamination, these Ca/Ba@alginate adsorbents will find applications in ultra-refining of lithium in industry.

关键词： barium@alginate microcapsules dropwise injection sulfate removal lithium

HTML PDF 收藏

OFDM直接变频接收机中通用的I/Q不平衡估计与补偿方法 None

Fang-lin GU, Shan WANG, Wen-wu WANG

《信息与电子工程前沿（英文）》 2018年第19卷第3期页码 388-397 doi: 10.1631/FITEE.1700003

摘要：直接变频接收机由于具有低功耗的特点，受到广泛关注，但是它存在较严重的同相/正交（I/Q）分量不平衡问题：I/Q不平衡会恶化接收信号的信噪比，进而影响系统的传输容量和能够支持的调制方式。本文首先分析了I/Q不平衡对OFDM接收机接收信号的影响，在此基础上，定义了一个统计量用于刻画OFDM系统的I/Q不平衡特性，并提出一种实现I/Q不平衡参数估计与补偿的方法。仿真结果表明，该方法可以实现对OFDM系统I/Q不平衡的准确估计与补偿，使补偿后系统的误比特率性能接近于不存在I/Q不平衡的情形。

关键词：同相/正交分量不平衡；正交频分复用；标准独立

HTML PDF 收藏

标题作者时间类型操作

Clinical significance of CD34⁺CD117^dim/CD34⁺CD117^bri myeloblast-associated gene expression in t(8;21) acute myeloid leukemia

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

期刊论文

Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

期刊论文

An approach for evaluating fire resistance of high strength Q460 steel columns

Wei-Yong WANG, Guo-Qiang LI, Bao-lin YU

期刊论文